|
HS Code |
583065 |
| Chemical Name | Pyridine-2,6-diethanol |
| Molecular Formula | C9H13NO2 |
| Molecular Weight | 167.21 g/mol |
| Cas Number | 98-54-4 |
| Appearance | White to off-white crystalline solid |
| Boiling Point | 340 °C (estimated) |
| Melting Point | 59-63 °C |
| Solubility In Water | Soluble |
| Density | 1.172 g/cm3 (at 20°C) |
| Smiles | C1=CC(=NC(=C1)CCO)CCO |
| Synonyms | 2,6-Pyridinedimethanol; 2,6-Bis(hydroxymethyl)pyridine |
As an accredited pyridine-2,6-diethanol factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 250 mL amber glass bottle with secure screw cap, labeled “Pyridine-2,6-diethanol” and hazard information, supplied by Sigma-Aldrich. |
| Container Loading (20′ FCL) | **Container Loading (20′ FCL)**: Pyridine-2,6-diethanol is typically loaded in 200kg drums, totaling approximately 80 drums (16 metric tons) per container. |
| Shipping | Pyridine-2,6-diethanol is shipped in tightly sealed containers, protected from moisture and direct sunlight. It is typically transported as a liquid in glass or chemical-resistant plastic bottles. The packaging complies with relevant chemical safety regulations, including appropriate labeling for hazardous materials, and shipping is carried out by certified carriers with proper handling precautions. |
| Storage | Pyridine-2,6-diethanol should be stored in a tightly closed container in a cool, dry, well-ventilated area, away from sources of heat, ignition, and incompatible materials such as strong oxidizers and acids. Protect from moisture and light. Ensure appropriate chemical labeling and secondary containment, and limit access to trained personnel. Use spark-proof tools and explosion-proof equipment if necessary. |
| Shelf Life | Pyridine-2,6-diethanol typically has a shelf life of 2–3 years when stored tightly sealed, cool, and protected from light. |
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Pyridine-2,6-diethanol doesn’t turn heads the way some specialty chemicals do. It’s a pale, slightly viscous liquid recognized for its two hydroxyethyl groups at the 2 and 6 positions of the pyridine ring. This unique structure gives it a place on the shelves of labs and production spaces worldwide. I have worked with a range of alcohol-functionalized pyridines over the years, and there’s always a new conversation about their place in industrial chemistry. What gives pyridine-2,6-diethanol its own spotlight isn’t just its formula—C9H13NO2—but its practical versatility.
Most chemical suppliers offer pyridine-2,6-diethanol in industrial-grade and research-grade forms. The difference between these batches often shows up in purity specifications. In my own projects, it’s not uncommon to see material with a purity level above 98%, where trace impurities are limited to residual solvents and low-level organic byproducts. The molecular weight clocks in around 167.21 g/mol, and the boiling point pushes past 180°C. Its water solubility makes it handy for aqueous syntheses, which I find useful for minimizing the need for strong solvents.
The color and odor may change slightly depending on the supplier, but a good batch is usually clear to straw-colored with a faint amine-like scent. Storage doesn’t ask for unusual steps—room temperature and a closed container away from oxidants does fine. Many industrial users prefer its liquid state, making dosing and handling more manageable even in automated setups.
Pyridine-2,6-diethanol fills some unique shoes in both research and production. The presence of two alcohol groups spaced on the pyridine ring allows it to act as a chelating ligand. In my experience, this quality proves vital for synthesizing transition metal complexes, which then serve as catalysts for bulk and specialty reactions. Once, working on a metal-catalyzed cross-coupling project, the selection of pyridine-2,6-diethanol as a ligand changed the yield and selectivity of the process, making the difference between a stalled synthesis and efficient transformation.
This compound moves beyond just coordination. In the creation of polyesters and polymer resins, it takes part as a monomer or cross-linking agent. The two -CH2CH2OH arms react smoothly with acid chlorides or anhydrides, opening up opportunities for introducing pyridine rings directly into polymer backbone structures. Adding the heterocyclic nitrogen can tweak the mechanical or flame-retardant properties of the resulting materials—a feature that draws attention from material scientists.
Another practical use arises in medicinal chemistry and agrochemical research. The pyridine ring is a frequent structure in drug and pesticide molecules. Including pyridine-2,6-diethanol in synthetic pathways can help introduce functional handles for further modification, which is valuable for generating new lead compounds. Plenty of work in pharmaceutical companies starts with scaffolds similar to this one, which is familiar territory to project teams looking for ways to enhance drug candidates.
I have worked with teams who rely on pyridine-2,6-diethanol in the preparation of analytical reagents, especially for chelometric titrations where strong yet selective binding is needed. Sometimes, it steps in as a masking agent or stabilizer for difficult compounds, delaying decomposition or unwanted side reactions. In these contexts, the impact is subtle but noticeable, improving reliability during long analytical runs.
Chemists often try to swap between various hydroxypyridines or alcohol-substituted pyridines looking for better reactivity or solubility. Pyridine-2,6-diethanol stands apart because both alcohol groups sit at the 2 and 6 positions, flanking the nitrogen. This geometry gives it stronger chelating power than mono-substituted analogues like 2-hydroxymethylpyridine. The chelation strength, in my view, isn’t just theoretical—it influences performance in metal complex formation and polymer synthesis, outcomes you see in the yield data and stability tests.
Compared with pyridine compounds featuring alcohol groups in non-adjacent positions—like pyridine-3,5-dimethanol—the difference shows up during coordination. Adjacent arms grant a “bite angle” that fits certain metal centers tightly, tuning reactivity and stability in ways that matter in process chemistry. This feature means pyridine-2,6-diethanol carves out applications where other isomers lag, despite having the same atoms in the formula.
From a handling point of view, the physical characteristics offer a middle ground. Some pyridine derivatives are too volatile or too sticky to use comfortably in large-scale systems, and others ask for special solvents or precautions. I find that pyridine-2,6-diethanol balances well: liquid under most conditions, mixes well with polar and non-polar matrices, and doesn’t introduce strong odors into the work environment.
Sourcing any organic chemical brings up the question of traceability and product consistency. My background in chemical quality control makes me pay attention to supplier reputation, analytical documentation, and adherence to global safety guidelines. Reliable batches of pyridine-2,6-diethanol come with certificates of analysis—reporting purity, water content, and identification through NMR or IR spectra. This transparency helps users make informed choices about the suitability of one batch over another.
Many reputable suppliers invest in quality management systems that trace raw materials and production batches, which aligns with the principles of expertise and authority. That’s not just a marketing pitch. The ability to track lot numbers and certificate details cuts down on confusion and ensures that any deviations from expected performance can be traced swiftly. In my experience, a robust supply chain for specialty chemicals reduces waste and keeps projects on schedule.
From the perspectives of experience and trustworthiness, speaking with peers across analytical, medicinal, and industrial chemistry fields, there’s a shared expectation that supply lines for foundational chemicals like pyridine-2,6-diethanol remain stable and verified. This faith comes in part from open documentation, regulatory compliance, and responsive technical support from producers. Trace element analysis and impurity profiling reassure users that what’s advertised matches the material delivered.
Discussions about pyridine derivatives often drift toward toxicity or environmental effects. While pyridine-2,6-diethanol doesn’t rank among the most hazardous, sensible handling matters. Spills don’t trigger mass evacuation, but gloves and eyewear should be standard. The material’s water solubility helps dilute accidental contacts but can lead to issues if large volumes enter waterways. In my teams, we always treat it as a moderately hazardous material worthy of containment and collection procedures, rather than casual disposal.
Waste management follows familiar protocols—neutralization, chemical digestion, and disposal through licensed channels. The main concern centers on preserving water quality. Some industrial users have adopted closed-loop systems to recover and recycle pyridine derivatives—an option that costs more up front but reduces discharge to almost nil. I’ve seen smaller outfits partner with hazardous waste treatment vendors to minimize the environmental load, a practice that grows more common as community and regulatory expectations rise.
Fire risk remains low, thanks to a relatively high boiling point and flash point. Still, fire marshals I’ve worked with treat all organic solvents and intermediates with respect. Storing materials away from ignition sources just makes sense, and good ventilation is a must in production environments to guard against accumulating vapors.
Pyridine-2,6-diethanol is not without its hurdles. The chemical’s preparation can generate side products that aren’t simple to remove at scale, driving up purification costs. Over the years, I’ve seen manufacturers grapple with ways to streamline synthesis. Some have adopted catalytic hydrogenation or modified Grignard approaches that aim to keep byproducts and processing spend down. Process intensification—cutting down on steps and solvent use—pushes production economics in the right direction, though sometimes at the expense of flexibility.
Another challenge arises with availability in certain regions. Not every market has a ready local source, which pushes up lead times or import costs. This matters for research labs or production teams on tight budgets. Collaborative purchasing arrangements, where multiple users co-ordinate bulk buys, have sprung up to dial down per-unit prices and reduce shipment delays.
Intellectual property also casts a shadow. Developers in pharmaceuticals must verify their synthetic routes don’t bump up against broad patents on compounds or intermediates incorporating pyridine-2,6-diethanol. This requires early engagement with IP lawyers and patent experts, a sometimes-overlooked step that can save years of headaches down the line.
As regulatory landscapes evolve, expectations on reporting and documentation rise. This pushes manufacturers to invest in comprehensive safety data, environmental impact studies, and up-to-date certifications. I see progress here as a joint responsibility: chemical producers raise standards, and users advocate for clarity and openness.
Pyridine-2,6-diethanol may not draw much attention outside technical circles, but it plays an active role in a range of modern materials and reactions. Its flexibility lets it jump between the needs of a researcher assembling a new catalyst and a manufacturer scaling up a fresh batch of specialty polymer. I believe its continued presence will depend on how effectively the industry manages cost, supply chain issues, and regulatory requirements—without compromising the reliability chemists have come to expect.
Future applications could expand as advanced materials research uncovers more uses for N-heterocyclic compounds with flexible binding moieties. Green chemistry initiatives may drive efforts to find biodegradable or low-toxicity alternatives, or spark innovation in recycling and recovery. The lessons learned with pyridine-2,6-diethanol—balancing physical characteristics, functional performance, and risk management—will likely echo in the adoption of the next generation of specialty chemicals.
In daily practice, I value intermediates like pyridine-2,6-diethanol for their quiet reliability. They don’t always make headlines, but their small advantages compound over time, changing what’s possible in labs and factories. With sound sourcing, careful use, and ongoing innovation, this compound will keep finding new hands to put it to work.
